Yesterday, August 21, was National Senior Citizens Day, a good opportunity to recognize older adults and reflect on what supports healthier aging. Medication safety is an important part of that, since the benefits, risks, and burdens of medications can change as we get older.

If you’re helping an older person with health and healthcare, chances are that person is taking at least a few prescription medications, if not several.

Do you ever wonder if he or she is on the right medications? Do you worry about side-effects and interactions?

These are sensible concerns to have. Many older adults end up experiencing “polypharmacy,” which means taking more than 5 medications concurrently.

And although medications do often help maintain health and wellbeing, studies have repeatedly shown that lots of older adults end up suffering from problems related to medication.

Polypharmacy, predictably, increases the risk of problems.  (Polypharmacy is usually defined as taking five or more medications concurrently.) But even older adults taking one to three daily medications can encounter problems.

So I want to share a list of common ways that medications affect the health and wellbeing of aging adults. I’ll then explain what you can do, to minimize these problems.

Six Common Medication-Related Problems in Aging Adults

Here are the most common problems that I see:

1. Side-effects affecting thinking and balance

Although all medications can cause side-effects, quite a few commonly used drugs are known to make thinking and balance worse in aging adults. These include:

• • Drugs in a class known as “anticholinergics,” which includes drugs for overactive bladder, itching/allergy, vertigo, nausea, and certain drugs for nerve pain or depression. Diphenhydramine, or Benadryl, is a commonly used anticholinergic that’s often included in over-the-counter sleep aids and PM-version painkillers. (Wondering how to spot these medications? I have a link to a great list of anticholinergics in this post.)
  • Sedatives and tranquilizers, which are often prescribed for sleep or for anxiety. Examples include zolpidem and lorazepam (brand names Ambien and Ativan, respectively).
  • These drugs can increase fall risk, or can provoke confusion. Geriatricians commonly recommend stopping or reducing the dosage of these drugs. For more information about four types of medication that affect memory, see here. For a list of medications that increase falls, see “10 Types of Medications to Review if You’re Concerned About Falling“.

2. Symptoms persisting despite drug treatment

Many older people are started on a drug for a certain symptom, such as pain, heartburn, incontinence, or depression. But because primary care visits tend to be busy, it’s easy for doctors — and even patients — to postpone following up on the symptom indefinitely. (Many symptoms would benefit from non-drug treatment too, but that’s another issue.)

• • In many cases, a “starter dose” is prescribed, but is not adjusted.
  • Older adults may end up with the risks and burden of taking a drug — including the cost of the drug — while not getting much benefit from the drug.
  • Geriatricians usually try to make sure that all drugs for symptoms are serving a useful purpose in improving well-being or quality of life.

3. Side-effects due to a strong effect of drugs on the older person

Examples of this include:

• • Blood pressure medications at a dose that brings blood pressure much lower than the goal blood pressure. This can result in lightheadedness, or even falls, when an older person stands. (See this post and this post for my recommendations on safer managing of blood pressure in older adults.)
  • Blood sugar that is pushed quite low by diabetes drugs. Low blood sugar episodes can cause falls and have been linked to faster cognitive decline. Drugs that lower blood sugar are involved in many medication-related hospitalizations.

4. Burden of scheduling and taking medications

Many older adults end up with several pills to take at several different times per day. At a minimum this is often a hassle; at worst it becomes a serious drain on quality of life.

• • Some older adults are unable to take all their medications properly. Depending on which medications are missed, this can cause serious effects on an older person’s health.

5. Cost of medications

Even with prescription drug coverage provided by Medicare Part D, the monthly costs of medications can be high. This is a burden for older adults, who often have limited financial resources.

• • It can also cause people to skip taking certain medications, or not fill prescriptions for more expensive medications (such as inhalers).

6. Drug interactions

This is one of the reasons polypharmacy can be so risky: some drugs tend to interact with others. A frequent source of problems in the past was the blood thinner warfarin (brand name Coumadin), which can interact with antibiotics as well as with other drugs.

• • Warfarin is one of the most common causes of medication-related hospitalizations in older adults.
  • Newer blood thinners have fewer drug interactions but can still cause dangerous effects when combined with certain other medications.
  • Many other drugs can cause interactions. You can check your medications using an online tool, such as this drug interaction checker.

There are of course many other medication-related problems that can occur, especially when hospitalizations or multiple doctors are involved. But the ones above are especially common when it comes to the primary care of aging adults.

How to avoid medication problems in aging

In an ideal world, every older adult would have access to a reliable process for reviewing medications, ensuring that the benefits outweigh the risks and burdens, and monitoring for side-effects and problems.

However, as many of you know, our healthcare system is not yet ideal for aging adults. So if you’re older — or are caring for an older person — and want to be proactive about checking on medications, here are some specific things you can do:

• Learn about the Beers List of Potentially Inappropriate Medications for Older Adults, and see if your older relative is taking medications on the list. This document includes a comprehensive list of “anticholinergic” drugs, and also lists other medications that are especially risky for the elderly.
  • Don’t panic if you discover that an older person is taking a medication on the Beers list. Do plan on discussing with the doctor. You’ll want to understand why the benefits are likely to outweigh the burdens, and you can also ask if a lower dose is possible.
  • You can also review “Ten Medications Older Adults Should Avoid or Use with Caution,” authored by the American Geriatrics Society. This document highlights ten especially commonly used medications that can often be stopped or reduced.
  • If you need help spotting risky medications, consider asking a pharmacist for assistance.

• Make a comprehensive list of all medications being taken. Include prescription drugs, over-the-counter drugs, and herbal supplements. Then, for every drug being taken, make sure you and family understand:
  • The purpose of taking the drug. Ask yourselves if the drug seems to be serving its purpose. If you aren’t sure, plan to ask the doctor. If it’s a drug to manage a symptom such as pain, consider how the symptom seems to be doing. If the doctor hasn’t reassessed the symptom lately, or if the symptom is still bothersome, you’ll want to discuss with the doctor.
  • If there are alternatives to taking the drug. Especially when it comes to treating symptoms, there are often non-drug alternatives that can and should be considered. For instance, certain types of counseling can be effective for depression and anxiety. Physical therapy can help treat some forms of pain. Pelvic floor exercises and timed toileting can reduce incontinence.
  • If a lower dosage is possible. In general, the risk of side-effects and problems goes up with higher doses of medication. Consider asking if a lower dose is possible for any of the medications.

• Ask your health providers about “deprescribing”. Deprescribing means reducing or stopping medications that may not be beneficial or may be causing harm. It’s second nature to geriatricians, but now other primary health providers are also being encouraged to do this with older patients, to reduce the risks associated with polypharmacy.
  • Randomized clinical trials have proven that giving older adults an informative brochure about their risky medications, along with a deprescribing plan to discuss with their doctor, does lead to actual deprescribing.
  • Learn more here: Deprescribing: How to Be on Less Medication for Healthier Aging.

• If you’re concerned about drug-drug interactions, have the medication list checked for possibly dangerous interactions.
  • Don’t forget to include any over-the-counter drugs or supplements when you check for interactions.
  • You can use an online drug interaction checker such as this one, or ask a pharmacist for help.
  • If you identify a potentially problematic interaction, let the doctor know as soon as possible. But don’t stop the medication on your own, as that can be dangerous too.

• If cost is an issue, ask the doctor about options for reducing the medications, or at least switching to less expensive alternatives.
  • For instance, stopping a medication that is not working well for a symptom can help reduce drug costs.
  • If medication is required for a given problem, such as very high blood pressure, ask if there is a cheaper medication available.
  • Pharmacists may be able to offer suggestions regarding less costly alternatives, or other ways to modify the medication plan.
  • You can also try to switch to a different Medicare Part D plan during Open Enrollment (which runs from October to December every year).

• If taking medications on schedule is an issue, ask the doctor for help simplifying and streamlining the daily medication plan.
  • For drugs taken several times a day, there may be a once-a-day option.
  • Or ask whether a drug can be stopped, and a non-drug treatment tried instead.
  • Pharmacists can often recommend ways to safely adjust when and how medications are taken.
  • An automated dispenser can also be helpful.

• Keep the doctors well-informed about medications and medication use. In particular, help the doctors avoid these two common pitfalls:
  • Confusion as to what has been prescribed by other doctors. Most older adults see multiple doctors, and hospital stays can create additional changes to the medication list. Don’t assume that doctors have an up-to-date list. (They almost never do!) Instead, bring an up-to-date list every time you see the doctor, or better yet, bring the bottles along too. Don’t forget to include supplements and over-the-counter drugs.
  • Confusion as to what an older person is actually taking. If you are helping a relative and they haven’t filled a prescription due to cost, or aren’t taking a medication for any reason, be sure to let the doctor know this. This is especially important if the older person has had concerns about side-effects.

By implementing some — or ideally all — of the steps above, you can help make sure that an older person gets the most benefit from medications, while minimizing the risks and burdens.

For more on medication safety, see “How to Review Medications for Safety & Appropriateness,” or see my Medication Safety topic page.

This article was last updated in August 2026.